The Basel Signaling Alliance is a center of excellence at the University of Basel. Signal transduction pathways are important in fundamental biology, controlling several basic biological processes including growth, development, aging and death. Furthermore, dysregulation of signaling pathways is the molecular basis of major diseases including cancer, diabetes, inflammatory disease, and cardiovascular disease. Our aim is to further elucidate cellular signaling pathways. The ultimate goal is to understand the underlying molecular defects in major disease and to improve patient diagnosis and treatment.