The interdisciplinary projects of the lab seek to elucidate the integrated effects of signaling pathways and epigenetics on breast cell fate and tumor heterogeneity, and to leverage this mechanistic understanding into therapy. To this end, we collaborate with clinicians and have built a Breast Cancer Personalized Medicine Team that should ultimately improve treatment for patients, from Basel, and throughout the world.
For these studies, we use primary derived xenografts (PDX), 3D cultures, multi-omics, and computational biology.
