Personalized medicine

piece-personalized-medicineThe interdisciplinary projects of the lab seek to elucidate the integrated effects of signaling pathways and epigenetics on breast cell fate and tumor heterogeneity, and to leverage this mechanistic understanding into therapy. To this end, we collaborate with clinicians and have built a Breast Cancer Personalized Medicine Team that should ultimately improve treatment for patients, from Basel, and throughout the world.

For these studies, we use primary derived xenografts (PDX), 3D cultures, multi-omics, and computational biology.

PDX to identify mechanisms of resistance
PDX to identify mechanisms of resistance From Ramos and Bentires-Alj. Oncogene 2014