Non-cell autonomous mechanisms of resistance and metastasis

piece-non-cell-autonomous-mechanism-ofWe are exploring non-cell autonomous mechanisms of breast cancer metastasis and resistance to therapy. We focus on the effects of the tumor microenvironment on cancer cell dormancy and metastasis. We study mechanisms of immune tolerance and  investigate combinations of targeted therapy and immunotherapy.

For these studies, we use multiphoton intravital imaging of tumor-host interactions.

Microenvironment-mediated resistance
Microenvironment-mediated resistance From Ramos and Bentires-Alj. Oncogene 2014